Bruce Furie Selected Research

Protein Disulfide-Isomerases

1/2019	Targeting protein disulfide isomerase with the flavonoid isoquercetin to improve hypercoagulability in advanced cancer.
12/2017	Protein disulfide isomerase inhibition blocks thrombin generation in humans by interfering with platelet factor V activation.
1/2017	Protein disulfide isomerase secretion following vascular injury initiates a regulatory pathway for thrombus formation.
9/2015	Quercetin-3-rutinoside Inhibits Protein Disulfide Isomerase by Binding to Its b'x Domain.
4/2015	Both platelet- and endothelial cell-derived ERp5 support thrombus formation in a laser-induced mouse model of thrombosis.
3/2015	Defective PDI release from platelets and endothelial cells impairs thrombus formation in Hermansky-Pudlak syndrome.
1/2015	Therapeutic implications of protein disulfide isomerase inhibition in thrombotic disease.
3/2014	Thiol isomerases in thrombus formation.
10/2012	Formation of the clot.
7/2012	Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrins.

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Bruce Furie Research Topics

Disease

46	Thrombosis (Thrombus) 01/2019 - 10/2002
11	Vascular System Injuries 01/2019 - 10/2002
8	Neoplasms (Cancer) 01/2019 - 02/2006
4	Inflammation (Inflammations) 09/2012 - 05/2005
2	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 07/2014 - 03/2011
2	Neoplasm Metastasis (Metastasis) 11/2009 - 02/2006
1	Hearing Loss (Hearing Impairment) 01/2020
1	Renal Insufficiency (Renal Failure) 01/2020
1	Thrombophilia 01/2019
1	Venous Thrombosis (Deep-Vein Thrombosis) 01/2019
1	Pulmonary Embolism 01/2019
1	Body Weight (Weight, Body) 04/2015
1	Hermanski-Pudlak Syndrome (Hermansky-Pudlak Syndrome) 03/2015
1	Mental Disorders (Mental Disorder) 01/2015
1	Poisoning 01/2015
1	Venous Thromboembolism 02/2013
1	Hemolysis 09/2012
1	Paroxysmal Hemoglobinuria (Paroxysmal Nocturnal Hemoglobinuria) 09/2012
1	Fatigue 09/2012
1	Coronary Artery Disease (Coronary Atherosclerosis) 02/2012
1	Atherosclerosis 02/2012
1	Hypercholesterolemia 02/2012
1	Graft vs Host Disease (Graft-Versus-Host Disease) 08/2010
1	Prostatic Neoplasms (Prostate Cancer) 11/2009
1	Pancreatic Neoplasms (Pancreatic Cancer) 11/2009
1	Hemophilia A (Haemophilia) 04/2008
1	Hemorrhage 06/2007

Drug/Important Bio-Agent (IBA)

21	FibrinIBA 01/2019 - 10/2002
18	Thromboplastin (Tissue Factor)IBA 01/2016 - 10/2002
13	Protein Disulfide-IsomerasesIBA 01/2019 - 03/2008
12	Proteins (Proteins, Gene)FDA Link 01/2019 - 07/2004
9	P-SelectinIBA 09/2012 - 06/2003
8	IsomerasesIBA 01/2019 - 10/2012
7	Sulfhydryl Compounds (Thiols)IBA 01/2019 - 10/2012
6	Thrombin FDA Link 09/2012 - 11/2004
3	FlavonoidsIBA 01/2019 - 01/2015
3	QuercetinIBA 01/2019 - 01/2015
3	AnticoagulantsIBA 12/2017 - 06/2003
3	Rutin (Rutoside)IBA 09/2015 - 06/2012
3	Fibrinogen (Factor I)FDA Link 07/2014 - 08/2005
3	Prothrombin (Factor II)IBA 07/2011 - 05/2007
2	EnzymesIBA 01/2020 - 09/2015
2	isoquercitrinIBA 01/2019 - 12/2017
2	AntibodiesIBA 01/2018 - 03/2011
2	Fibrinolytic Agents (Antithrombotic Agents)IBA 01/2017 - 06/2012
2	Plasminogen Activator Inhibitor 1IBA 01/2017 - 10/2016
2	Oxidoreductases (Dehydrogenase)IBA 09/2015 - 06/2012
2	Vitamin K FDA Link 01/2015 - 06/2007
2	AutoantibodiesIBA 07/2014 - 03/2011
2	Eptifibatide (Integrilin)FDA Link 07/2014 - 11/2010
2	Monoclonal AntibodiesIBA 09/2012 - 03/2008
2	Biomarkers (Surrogate Marker)IBA 03/2011 - 05/2007
2	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 03/2011 - 02/2006
2	Biological ProductsIBA 03/2011 - 01/2009
2	Plasminogen Activators (Plasminogen Activator)IBA 03/2011 - 02/2006
2	E-SelectinIBA 11/2009 - 10/2002
2	LigandsIBA 11/2009 - 07/2005
2	Factor VIII (Coagulation Factor VIII)IBA 04/2008 - 05/2007
2	CalciumIBA 12/2007 - 04/2007
2	Collagen ReceptorsIBA 05/2006 - 03/2006
2	Glycoproteins (Glycoprotein)IBA 05/2006 - 07/2005
1	fibrin fragment D (D-dimer)IBA 01/2019
1	Pharmaceutical PreparationsIBA 01/2019
1	endoplasmic reticulum glycoprotein p72IBA 01/2018
1	VitronectinIBA 01/2017
1	AntigensIBA 01/2016
1	ThrombospondinsIBA 01/2016
1	DisulfidesIBA 01/2016
1	Adenosine Diphosphate (ADP)IBA 03/2015
1	Warfarin (Coumadin)FDA LinkGeneric 01/2015
1	RodenticidesIBA 01/2015
1	bromfenacoum (Ratak)IBA 01/2015
1	Antiphospholipid AntibodiesIBA 07/2014
1	Enoxaparin (Lovenox)FDA LinkGeneric 02/2013
1	Factor Xa (Coagulation Factor Xa)IBA 09/2012
1	Inositol (Myoinositol)IBA 09/2012
1	eculizumab FDA Link 09/2012
1	SelectinsIBA 09/2012
1	Complement System Proteins (Complement)IBA 09/2012
1	IntegrinsIBA 07/2012
1	Lipoproteins (Lipoprotein)IBA 02/2012
1	CholesterolIBA 02/2012
1	Simvastatin (Zocor)FDA LinkGeneric 02/2012
1	oxidized low density lipoproteinIBA 02/2012
1	PhosphatidylserinesIBA 07/2011
1	Membrane Proteins (Integral Membrane Proteins)IBA 04/2011
1	Anticardiolipin AntibodiesIBA 03/2011
1	Sepharose (Agarose)IBA 03/2011
1	Lupus Coagulation Inhibitor (Lupus Anticoagulant)IBA 03/2011
1	Immunoglobulin G (IgG)IBA 03/2011
1	Sialyl Lewis X AntigenIBA 11/2009
1	FucosyltransferasesIBA 11/2009
1	Hemostatics (Antihemorrhagics)IBA 01/2009
1	Bacitracin (Baci-Rx)FDA LinkGeneric 03/2008
1	bile salt-stimulated lipaseIBA 12/2007
1	glutamyl carboxylase (gamma-glutamyl carboxylase)IBA 06/2007
1	Factor V (Coagulation Factor V)IBA 06/2007

Therapy/Procedure

17	Lasers (Laser) 01/2017 - 10/2002
4	Therapeutics 09/2012 - 03/2006
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 08/2010